구순구개열 발생의 분자유전학 연구를 위한 유전자 표적/적중 생쥐모델의 이용
Gene Targeting Mouse Genetic Models for Cleft Lip and Palate
백진아,
소속 상세정보
백진아 ( Baek Jin-A ) - 전북대학교 치과대학 구강악안면외과학교실
KMID : 0952820080110020065
Abstract
Cleft lip and/or palate are common birth defects in humans and the causes including multiple genetic and environmental factors are complex. Combinations of genetic, biochemical, and embryological approaches in the laboratory mice are used to investigate the molecular mechanisms underlying normal craniofacial development and the congenital craniofacial malformations including cleft lip and/or palate. Both forward and reverse genetic approaches are used. The forward genetic approach involves identification of causative genes and molecular pathways disrupted by uncharacterized mutations that cause craniofacial malformations including cleft lip and/or cleft palate. The reverse genetic approach involves generation and analyses of mice carrying null or conditional mutations using the Cre-loxP mediated gene targeting techniques.
키워드
Gene targeting mouse model;Cre-loxP;Cleft lip and palate
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